Dental curing light may stunt tumour growth
The blue curing light used to harden dental fillings also may stunt tumour growth, researchers have found.
‘The light sends wavelengths of blue-violet light to the composite, which triggers hardening,’ said Alpesh Patel, of the Medical College of Georgia.
‘The light-waves produce free radicals that activate the catalyst and speed up polymerization of the composite resin. In oral cancer cells, though, those radicals cause damage that decreases cell growth and increases cell death.’
Mr Patel, who has been working with Dr Jill Lewis, associate professor of oral biology, Dr. Regina Messer, associate professor of oral rehabilitation and oral biology, and Dr. John Wataha, adjunct professor of oral rehabilitation and oral biology, studied 10 tumour-bearing mice, five treated with the light and five untreated.
He exposed half the mice to the blue light for 90 seconds a day for 12 days.
Then the tumours were extracted and each one was split into two sections.
Half were used to create slides for tissue analysis, and half were frozen to prepare protein extracts.
Tissue analysis indicated an approximate 10% increase in cell suicide, or apoptosis, in the light-treated tumours.
The frozen protein extracts revealed a nearly 80% decrease in cell growth in the light-treated tumours.
‘The decrease in cell growth, combined with increased apoptosis, helps explain why the tumours didn’t grow as much because you have cells that aren’t dividing and you have cells that are committing suicide,’ Mr Patel says.
Dr Lewis predicts treating the tumours with blue light sooner will increase the rate of apoptosis, possibly preventing the tumor from ever becoming measurable and easing treatment.
‘One desirable feature we’ve observed with the blue light is that non-cancerous cells appear unaffected at light doses that kill tumor cells,’ says Dr Lewis.
‘We’re thinking that some day, blue light therapy may serve as an adjunct to conventional cancer therapy.
‘Patients may, therefore, receive lower doses of chemotherapy, which would decrease the adverse effects most cancer patients experience from standard chemotherapy regimens.’