Proactive prevention has never been more important – empower every patient to achieve superior biofilm control

colgate total offering biofilm controlColgate Total explains how its unique toothpaste formula helps patients achieve superior biofilm control giving them whole mouth health.

Oral biofilms are complex, structured communities of bacteria that live throughout the whole mouth – on teeth, tongue, cheeks and also gums.

Biofilm accumulation leads to dysbiosis. Clinicians recognise it as the primary cause of common oral diseases such as caries and periodontal disease and of concerns like tartar and malodour.

Uncontrolled biofilm can, therefore, put everyone at risk (Sanz et al, 2017). So how can we keep it under control?

Achieving whole mouth health

Effective biofilm management is a key strategy for prevention and also for successfully achieving whole mouth health.

Oral biofilms have defence mechanisms that make them difficult to control.

One defence mechanism is the synthesis of extracellular polymeric substance (EPS) that many bacteria secrete. EPS allows bacteria to stick together and therefore defend the biofilm from antibacterial attacks.

Colgate Total, formulated with dual-zinc and arginine, has the ability to de-structure the EPS. It works in three proven ways:

  • Uniquely penetrates deep into biofilm arginine in Colgate Total interferes with the EPS and therefore destabilises the biofilm. This allows zinc to penetrate and accumulate deep into the biofilm. Here it can exert its antibacterial action (Manus et al, 2018; Colgate data on file)
  • Disrupts biofilm to reduce biofilm mass – dual-zinc and arginine Colgate Total also penetrates the biofilm. Dual-zinc and arginine starts disrupting the biofilm architecture (Colgate data on file)
  • Inhibits further sustained bacterial regrowth – dual-zinc and arginine in Colgate Total provides less bacterial regrowth after 12 hours versus a traditional fluoride toothpaste
  • (Colgate data on file).*

These in-vitro studies support that Colgate Total with dual-zinc and arginine helps control biofilm. Consequently it uniquely penetrates, disrupting and inhibiting biofilms for 12 hours.

Click here to find out more.

Highly effective in controlling bacteria, Colgate Total with dual-zinc and arginine therefore enables superior biofilm control (Manus et al, 2018, Colgate data on file).*

An in-vitro study shows that Colgate Total is highly effective in controlling bacteria across the whole mouth and also in saliva. Clinical findings reveal reductions up to 41% higher than those obtained through brushing with a regular fluoride toothpaste alone (Prasad et al, 2018).

Superior clinical outcomes #,*

Furthermore, numerous clinical studies confirm superior# clinical outcomes (Colgate data on file; Hu et al, 2018). This demonstrates significantly better control of plaque, gum problems, tartar and malodour, compared to a standard non-antibacterial sodium fluoride toothpaste.

  • Plaque reduction – 34.4% (Colgate data on file)^
  • Malodour reduction – 30.8% (Hu et al, 2018)^
  • Reduction in gum problems – 26.6% (Colgate data on file)^
  • Reduction in tartar – 40.1%. (Colgate data on file)^

Colgate Total is the advanced way to achieve whole mouth health by proactively controlling and also protecting against bacteria on 100% of mouth surfaces, teeth, tongue, cheeks and gums. ††

Empower every one of your patients by recommending Colgate Total. So they can achieve superior biofilm control (Manus et al, 2018; Colgate data on file)†† for better, more complete oral health.

Click here for further information on how you can achieve effective biofilm management with Colgate Total.


* Colgate Total provides superior in-vitro delivery, penetration, and retention of zinc. Through arginine technology for biomass reductions versus zinc control toothpaste.

† mass spectrometry images of salivary 10-day biofilms treated once with toothpaste slurry and regrown overnight under constant artificial salivary flow (10 mL/hr).

‡ confocal images of established salivary 40-hour biofilms grown in-vitro under flow. Then treated once for two minutes with water control (top) or dual-zinc and arginine technology (bottom).

§ Bacterial biofilms imaged after one treatment with either non-antibacterial fluoride toothpaste or dual zinc and arginine toothpaste slurry followed by a 12-hour regrowth period.

# Compared with non-bacterial sodium fluoride toothpaste.

^ Statistically significant reduction versus non-antibacterial fluoride toothpaste.

†† versus ordinary non-anti-bacterial fluoride toothpaste.

Hu D, Zhang X, Zhong Y, Mateo LR, Dibart S and Delgado E (2018) A Clinical Investigation of the Efficacy of a Dual Zinc plus Arginine Dentifrice for Controlling Oral Malodor. J Clin Dent 29 (Spec Iss A): A41-45

Manus LM, Daep CA, Begum-Gafur R, Makwana E, Won B, Yang Y, Huang XY, Maloney V, Trivedi HM, Wu D and Masters JG (2018) Enhanced In Vitro Zinc Bioavailability through Rational Design of a Dual Zinc plus Arginine Dentifrice. J Clin Dent 29 (Spec Iss A): A10-19

Prasad KV, Therathil SG, Agnihotri A, Sreenivasan PK, Mateo LR and Cummins D (2018) The Effects of Two New Dual Zinc plus Arginine Dentifrices in Reducing Oral Bacteria in Multiple Locations in the Mouth: 12-Hour Whole Mouth Antibacterial Protection for Whole Mouth Health. J Clin Dent 29 (Spec Iss A): A25-32

Sanz M, Beighton D, Curtis M, Cury J, Dige I, Dommisch H, Ellwood R, Giacaman R, Herrera D, Herzberg M, Könönen E, Marsh P, Meyle J, Mira A, Molina A, Mombelli A, Quirynen M, Reynolds E, Shapira L and Zaura E (2017) Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease. J Clin Periodontol 44(Suppl 18): S5–S11

Get the most out of your membership by subscribing to Dentistry CPD
  • Access 600+ hours of verified CPD courses
  • Includes all GDC recommended topics
  • Powerful CPD tracking tools included
Register for webinar
Add to calendar