Communication key to prevent rare bone disease

New research has found that better communication between dentists, pharmacists and doctors could prevent a rare bone disease in some patients with osteoporosis and cancer

Certain dental procedures, such as tooth extractions, can provoke a condition known as osteonecrosis – or bone death – in patients taking biophosphonates, the most common treatment for osteoporosis.

The drugs are also used as part of treatment for some cancers.

Osteonecrosis of the jaw is rare but is very difficult to treat and causes significant pain and occasionally surgery is used to remove the dead bone, but this can be unsuccessful as there is a reduced blood supply to the affected area.

The result can be disfiguring and often life-changing for patients.

University of Sunderland study

A study into the impact of the disease on patients, carried out by a team from the University of Sunderland, found that much more communication was needed between GPs prescribing the biophosphonates, pharmacists supplying the medicines and dentists managing patient’s oral health.

Lead researcher Andrew Sturrock who is the principal lecturer and programme leader for the Master of Pharmacy programme at the University of Sunderland, explained: ‘Although this condition is very rare, patients prescribed these medicines should have any dental treatment done before they start taking the drug.’

‘They also need to ensure they maintain good oral hygiene and good oral health whilst taking the medicine.

‘Our findings, however, established that this wasn’t happening. GPs and pharmacists weren’t telling people about the risks for all sorts of reasons; because the disease is so rare, it wasn’t a priority or it’s been forgotten about. In some cases, the patient didn’t disclose they were taking the medicine when needing to have dental treatment.

Dentists are definitely out of the loop and they need to be more involved in the care of this patient group at a much earlier stage.’

The team interviewed 23 patients nationwide, six of whom had developed osteonecrosis as a result of taking biophosphonates.

The remaining 17 participants all had been diagnosed with osteoporosis, of which 13 had been prescribed biophosphonates.


The study, funded by Pharmacy Research UK and the UK Clinical Pharmacy Association, found that patients placed trust in their health professionals and expected that the risks and benefits of any medication should be communicated when the medicines were first prescribed.

However, in most cases this didn’t happen, making it harder for patients to make informed decisions.

Many said their dentist did ask about drugs they were taken, but didn’t explain what the implications might be.

All participants in the study said they would be happy for their information to be shared between health professionals, including communication between doctors and dentists when biophosponates were prescribed.

Co-author of the paper, Philip Preshaw, professor of dentistry at the University of Singapore, said: ‘Medication-related osteonecrosis of the jaw is thankfully quite rare, but when it does occur it has a profound impact on patients’ quality of life and can cause significant levels of pain.

‘Prevention is always better than cure, and better communication between doctors, pharmacists and dentists would ensure that the dental team know which patients are going to start taking the implicated medications, so that they can assess and optimise their oral health before they start taking them, to reduce the risk of osteonecrosis developing later.’

Co-author Professor Scott Wilkes, head of the school of medicine, professor of general practice and primary care, University of Sunderland and part-time GP in North Tyneside, added: ‘GPs see a lot of patients who take bisphosphonate medications to protect against osteoporosis and Pharmacists dispense a lot of these medications everyday.

‘There are two opportunities missed for relatively simple interventions.

The first is brief advice from the GP or pharmacist to attend a dental check-up and the second is fully informed consent about the risk albeit uncommon.

‘Pharmacy may have an opportunity to embed such a service into a New Medicines Service. Although rare, it is a devastating disease and any reduction in the number of cases is welcome.’

The research has now been published in the BMJ Open:

Become a Dentistry Online member

Become a member
Add to calendar