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Nutritional influences on bisphosphonates and mandibular osteonecrosis
Over the past three years, several reports have been published on the possibility of mandibular osteonecrosis being associated with the administration of bisphosphonates. Bisphosphonates are highly active inhibitors of osteoclasts, preventing bone breakdown. They are analogs of a naturally occurring compound, pyrophosphate, that regulates calcium activity. Bisphosphonates have been known to chemists since the middle…