£600,000 for research in oral medicine

Dr Stefano Fedele and Professor Stephen Porter of the UCL Eastman Dental Institute have recently been awarded more than £600,000 in prestigious research grants and PhD scholarships.

The funding will support a number of clinical and translational research projects, which will be conducted at the UCL EDI.
Dr Fedele, senior clinical lecturer, and Professor Porter, institute firector, have received grants from the National Institute of Health Research – Research for Patient Benefit Scheme (NIHR-RfPB) and Arthritis Research UK, and been awarded a UCL Grand Challenge PhD Scholarship for work in relation to two research projects: LEONIDAS-1 and LEONIDAS-2.

These multi-centre studies will investigate the effectiveness of a novel medical device in lessening dry mouth symptoms caused by radiotherapy and Sjogren’s syndrome and have the potential to revolutionise the management of individuals affected by this debilitating disorder.
Dr Fedele and Professor Porter have also secured funding from the International Serious Adverse Event Consortium (iSAEC) and a second UCL Grand Challenge PhD Scholarship to lead an international research project on the genetics of bisphosphonate-related osteonecrosis of the jaws: the GENVABO study.

This is a genome-wide association study (GWAs) that will help to discover potential gene variants associated with the risk of developing jaw osteonecrosis. The results will enable clinicians to identify individuals genetically predisposed to this debilitating and incurable drug-induced adverse side effect.

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